Closure of perforation in root canal or perforation area. External or internal perforating root resorption treatment. Retrograde root canal filling ( under root tip resection ). Preservation of pulp vitality ( direct pulp capping, covering of pulp wounds after partial or total pulp amputation ). Apexification with Apiseal MTA :, Ions Calcium Release : Enhances formation of mineralized tissues provides biological seal of perforations and total repair of damaged periradicular tissues. Biological Action : Capable of inducing neoformation of periradicular cement. Easy to use : Does not lose properties due to moisture of oral tissues. High Alkalinity : Bactericidal, after mixing pH value is 1 and becomes 12 within 3 hours. Low solubility : Does not disintegrate, Biocompatible to oral tissues : Low inflammatory response. Adequate compressive strength : Can be used as a base restoration material. More Radiopaque than dentin and bone : Easy radiograph visibility.